Disease of apian spore bug is a kind of widespread grown bee disease. Often happen in early spring. It is by apian spore bug tiny helminth parasitism is in the bee bowel is epithelial inside the disease that cause. 1 . Lienal, bee has the feed that in transmitting way bee colony, is polluted by ill bee excrement and urine, nest is disease basically infects a source. Spore bug basically clears through office staff bee inside bee colony mew room and mutual the feed between travels. In the transmission between bee colony, advocate in the bee colony that if pass stray bee, pilfer bee, amalgamative bee colony,enters spore bug area health. In addition, the bee collects not clean water from cesspool edge, also can go back spore bug belt. 2. Pathology sicken bee, initial stage does not have apparent symptom. Arrived later period, because spore bug destroyed apian bowel mucous membrane, digestive dysfunction, hidebound, ill bee end of dejected, head nigrescent, wing quivers, cannot fly, crawl everywhere. And annulus lines is not distinct, lose flexibility and luster, in alvine expand, show hoar, discharge deep yellow and brown ribbon to have the excrement and urine of fishy flavour, accompany have next dysentery. 3. Method of prevention and cure 3. 1 prevents early spring, should choose the temperature outdoor the fine calm day of 12 ℃ above, timely the flight outside letting beehive is excreted. Discovery is ill group bee should change case in time, change lienal, change queen bee. 3. 2 medication ① makes up acerbity feed, in every kilogram syrup and sweet water, add gram of citric acid 1 , rejoin 1 - the chloromycetin of 200 thousand unit. ② Wuluotuopin, every kilogram syrup adds Wu Luo to hold the gram that taste 1 in the palm. ③ metronidazole, every kilogram syrup joins metronidazole 2 - 3. Every casing bee feeds dosage every time 50 - 100 gram, every other 3 - feed 1 4 days second, successive cure 4 - 5. To ill bee, can choose the above-listed either to plant medical fluid cure.